Various antibiotics are used to eradicate the bacteria that are responsible for the development of peptic ulcer disease pud. Research paper ulcer prevention effect of 3,4,5tihydroxyn0. This study is aimed to evaluate the effect of zingerone on ethanol induced gastric ulcers in rats. Quality of publications the main characteristics of the case reportsseries and the quality score derived from the ispeisop guidelines are shown in table 1. Idogun antiulcer herbal mixture is a potent antiulcer drug. The assessment was carried out by using ulcer index, ulcer score and histopathological studies of the specimens. Low ethanolconsuming and medium ethanolconsuming rats developed a similar incidence of these lesions, while high ethanolconsuming rats showed the lowest incidence of intestinal ulcer. A portion of the keratinized squamous epithelium of the tongue has been lost, exposing the underlying lamina propria. Ironically, nicorandil was found to be involved in the induction of oral ulcers in 1997 by reichert et al. Gastroprotective effect of zingerone on ethanolinduced. Classification of antiulcer drugs rtt functional group. Benzohydrazide in hclethanolinduced gastric international. Hyp1, a novel diamide compound, relieves inflammatory and.
Rats were administered intrarectal saline control group or acetic acid colitis model group. Research paper ulcer prevention effect of 3,4,5tihydroxy. In this study, the preventive effects of the crude extract of scutia buxifolia cesb against gastric ulcer induced by 70% ethanol were evaluated in male wistar rats. Gastric juice, gastric mucosa, morphologies of gastric ulcers and protein expressions of both. It is known that nitroglycerin gtn can be converted to form a nitric oxide no molecule which is a highly reactive and unstable free radical species. Protective role of phoenix dactylifera fruit against ethanol induced gastric ulcer in wistar rats background. Antiulcerogenic effect of cuphea ignea extract against ethanol. Rats were divided into six groups with three rats in each group.
Oral administration of camel milk in rats with ethanolinduced gastric ulcer. The aqueous extract of chamomile and liqurice and chamomile oil exhibited significant p ulcer activity in this ulcer induced models compared with omeprazole as standard drug. Pdf antiulcer activity of centella asiatica leaf extract. Atypical fractures of the femur and bisphosphonate therapy. The anti ulcer activity of hydro alcoholic extract of rhus coriaria linn. Gastroprotective effect of vanillin on indomethacininduced gastric.
Gastric ulcer was induced in rats and the ulcer size, mucosal epithelial cell proliferation of the ulcer margin, expression of growth factors epidermal growth factor egf, basic fibroblast. Garlic oil was evaluated for gastroprotective activity against ethanol induced ulcers. Conventional histology and immunohistochemistry for ghrelin, gastrin, and somatostatin were performed on gastric specimens from representative rats. The ameliorative effect of dates phoenix dactylifera l. Gastric ulcers were induced in sprague dawley rats using one oral dose of. The acetone extract of cucumis sativus seed reduces the paw edema induced by carrageenan by 43. The results obtained indicate that the acetone extract has significant antiinflammatory activity in rats. The aqueous extract of chamomile and liqurice and chamomile oil exhibited significant p pdf only article.
Thus, in an experimental model of gastritis induced by iodoacetamide, souza et al observed that, after the administration of aspirin 50 or 100 mgkg, the levels of lxa 4 in gastric mucosa of rats with gastritis were significantly higher than in healthy rats. Amelioration of severe tnbs induced colitis by novel ap1 and. Cassia sigueana, ethanol, antiulcer, preventive index, gastric ulcer, histopathology introduction peptic ulcer is a chronic, nonmalignant inflammatory disease characterised by ulceration in the upper gastrointestinal tract stomach and duodenum where parietal cells are found. Nursing care plan a client with peptic ulcer disease the client with cancer of the stomach worldwide, cancer of the stomach is the most common cancer other than skin cancer. Evaluation of the antiulcer effect of aerva javanica aerial. Pirenzapine propantheline oxyphenonium d prostaglandin analogues. The response beginning ranitidine covers the ulcer describes the action of sucralfate carafate. Druginduced peptic ulcer disease clinical pharmacist, st lukes hospital, guardamangia, malta email. Antiulcerogenic effects of a hydroethanol 70% extract. The incidence of gastric cancer is highest in hispanics,africanameri. Effect of cardiospermum halicacabum on ethanolinduced. Orally, after 45 min of methanolic extract and omeprazole treatment. Oleuropein prevents ethanolinduced gastric ulcers via.
In addition, the composition of cesb was clarified by highperformance liquid chromatography hplc. The rats were fasted for 24 hours before the oral gavage pretreatment food but not water. The goal for patients taking opioids is to have a bm at least every 23 days. The first experiment established an additional effect of no, that gtn can help. Antiulcerogenic effects of a hydroethanol 70% extract from stem bark of terminalia superba engl et diels combretaceae in rats and phytochemical screening free download as pdf file. Misoprostil enprostil 2 neutralization of gastric acid a systemic. Mild tissue edema and presence of inflammatory cells were observed in the omeprazole treated section. Antiulcer activity of centella asiatica leaf extract against ethanolinduced gastric mucosal injury in rats article pdf available in journal of medicinal plant research 4 july 2010 with. Omeprazole and misoprostol for preventing gastric mucosa. Drink 8 glasses of fluid per day if able include fiber in the diet. Differential reduction in preference for ethanol and ethanolpaired. Ghrelin protects against ethanolinduced gastric ulcers in. This study was designed to compare the rates of qouh achievement in rat gastric ulcer model between acid suppressant treated group and gastroprotectant treated group.
Effect of liqurice and chamomile extracts in the management. Effect of aspirin treatment on the prevention of esophageal. A predictable b uncontrollable c lowintensity d repeated page 1158 515. Reactive oxygen species are involved in the pathogenesis of these ulcers.
Quality of ulcer healing qouh is defined as ideal ulcer healing featuring with the fine granular ulcer scar, high functional restoration and the resistance to recurrence. Pheniramine maleate attenuates oleic acidinduced acute. This study was performed to determine the anti ulcer effects of ethanol extract of parkia speciosa on indomethacin induced peptic ulcer in albino rats. Protective role of phoenix dactylifera fruit against. Effect of ethanolic extract of coconut cocos nucifera on aspirininduced gastric ulcer in albino rats. Acute lung injury, antihistamine, ards, methylprednisolone, pulmonary edema acute respiratory distress syndrome ards is a common devastating clinical syndrome of acute lung injury with high mortality rate, 26 to 58%1,2. Protective role of phoenix dactylifera fruit against ethanolinduced gastric ulcer in wistar rats background.
The first page of the pdf of this article appears above. Cimetidine ranitidine pantaprazole b proton pump inhibitors. Water supplement had been removed two hours before oral pretreatment started. Rats were killed after 1 h of ethanol exposure, and the incidence and severity of the ulceration were estimated, as well as the concentrations of gastrin in plasma, and histamine and mucus in the. Fruit pulp extract on indomethacininduced gastric ulcer in albino. This study was performed to determine the antiulcer effects of ethanol extract of parkia speciosa on indomethacin induced peptic ulcer in albino rats. These features were absent in the ulcer induced rats that were subsequently treated with the idogun mixture. These results suggested a possible benefit of milk supplementation in treating peptic ulcer. Peptic ulcer, medicines, prostaglandins, gastrointestinal protection, gastrointestinal toxicity for more than a century, peptic ulcer disease has been a major cause of morbidity and mortality. Normal saline and ranitidine were used as negative and positive control. The antiulcer activity of hydro alcoholic extract of rhus coriaria linn. A family member of a 28yearold patient who has suffered massive abdominal trauma in an automobile accident asks the nurse why the patient is receiving famotidine pepcid. Peptic ulcers are gastrointestinal lesions that occur in the stomach and duodenum as a result of ethanol consumption, helicobacter pylori infection and use of non steroidal antiinflammatory drugs. Antiulcer activities of liquorice and its derivatives in experimental gastric lesion induced by ibuprofen in rats.
Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. The patient should not have hard stools or straining. Each was orally treated respectively with distilled water ulcer control group, omeprazole 20mgkg reference group and 100, 200, 400 and 800mgkg extract from idogun antiulcer. Evaluation of antiulcer activity of hydro alcoholic. Thus, the aim of this study was to assess the antioxidant abilities of oleuropein in comparison with ranitidine in ethanol induced gastric damages via evaluation of ulcer index inhibition, antioxidant enzyme activities, and lipid peroxidation level.
Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n. Pdf gastroprotective effect of zingerone on ethanol. The number of ulcers was counted by using the magnifying glass. Agricultural sciences correction for an inhibitor persistently decreased enteric methane emission from dairy cows with no negative effect on milk production, by alexander n. The use of sucralfate carafate along with antibiotics is the best combination therapy for peptic ulcer disease pud. Chronic wound healing in the skin nih guide, volume 22, number 29, august, 1993 rfa. National institute of arthritis and musculoskeletal and skin diseases national institute on aging national institute of child health and human development national institute of diabetes and digestive and kidney.
Finally, the same positive effect of the oral administration of camel milk was observed in rats with naproxeninduced peptic ulcers. The ulcer is the open sore in the lining of the stomach or intestine, similar to mouth ulcers stomatitis and skin ulcer. In these methods thermal and clampingcortisone ulcers seem to be valuable tools in investigation of the healing process of gastric ulcer, because of the relatively long period of its persistence and closer histologic resemblance to human peptic ulcer. Antiulcerogenic effect of camel milk against ethanol induced. Accelerated ulcer healing and resistance to ulcer recurrence. Duodenal ulcer is the ulcer that occurs in the first part of the intestine. Tongue ulcer in a female f344n rat from a chronic study. Effect of garlic oil on ethanol induced gastric ulcers in rats. The leading product in the market, nurofen plus, contains 200 mg ibuprofen and 12. Biochanin a gastroprotective effects in ethanolinduced. Idogun on the stomach of ulcer induced albino rats. The rats were allowed access to feed and water ad libitum for 48 h and observed for signs of toxicity and death. Peptic ulcers are gastrointestinal lesions that occur in the stomach and duodenum as a result of ethanol consumption, helicobacter pylori infection and use of nonsteroidal antiinflammatory drugs. No is known to have many beneficial effects such as relaxing blood vessels, promoting digestive activity, and regulating blood pressure.
The present study was performed to evaluate the antiulcerogenic activity of ethanol extract of centella asiatica against ethanolinduced gastric mucosal injury in rats. The gastric ulcers were induced in rats by administrating absolute ethanol 90% 1ml200g. Rats with acetic acid induced colitis were treated by intraperitoneal or intrarectal administration of nacetylcysteine 500 mg kg treated group. Thus, the aim of this study was to assess the antioxidant abilities of oleuropein in comparison with ranitidine in ethanolinduced gastric damages via evaluation of ulcer index inhibition, antioxidant enzyme activities, and lipid peroxidation level. Evaluation of the antiulcer effect of aerva javanica. Subcutaneous ghrelin administration 80 micro gkg reduced ulcer depth only. Evaluation of antiulcer activity of methanolic extract of.
Omeprazole lansoprazole pantoprazole rabeprazole c anti cholinergics. A preliminary study of the antiinflammatory and anti. Therefore, omeprazol is the choice for ulcer treatment along with the nsaids, taking as basis its efficiency, tolerance and safety20mg ideal dosage once a day 31,32. The fruit pulp was extracted with ethanol and the antiulcer activity of the extract in indomethacininduced gastric ulceration in swiss albino rats was.
Omeprazole 20 mgkg were used as a standard drug for. Antiulcer activity of centella asiatica leaf extract against ethanolinduced gastric mucosal injury in rats. Nitroglycerin relieves emotional stressinduced stomach. The effect of oral administration of raw camel milk 5 mlkg b. Protective role of phoenix dactylifera fruit against ethanol. Clopidogrel delays gastric ulcer healing in rats request pdf. The incidence of peptic ulcer is increased due to stress, smoking, alcohol, helicobacter pylori and ingestion of nonsteroidal antiinflammatory drugs nsaid 3, 4, 5.
Beneficial effects of nacetylcysteine on acetic acid. Tongue ulcer gallery tongue ulcer in a female f344n rat from a chronic study. Antiulcerogenic effect of camel milk against ethanol. Purified oleuropein from olive leaf extract has been shown to have antioxidant effects in our recent studies. Therapeutic value of camel milk as antiulcerogenic effect. They were kept in specially constructed cages to prevent coprophagia during and after the experiment. The possible involvement of garlic oil in restraining the oxidation process produced in gastric tissue was also investigated. Hpna managing opioid induced constipation teaching sheet. Gastric ulcer is the ulcer which occurs in the stomach.
Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg. Gastric ir injury was induced according to wada et al. Gastroprotective effect of zingerone on ethanol induced gastric ulcers in rats article pdf available in medicina kaunas, lithuania 553. Effect of ethanolic extract of coconut cocos nucifera on aspirin. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. The gastric ulcers were induced in rats of either sex weighing between 150 g by administrating absolute ethanol 8 mlkg. However, afterintravenous pretreatment with an antagonist of atpsensitive potassium channels glibenclamide, the ulcer lesions were increased. Ibuprofencodeine preparations first entered the australian overthecounter otc market in october 2002. Antiulcerogenic activity of scutia buxifolia on gastric. Gastric ulcer is one of the major gastrointestinal disorders, which occurs due to an imbalance between the offensive gastric acid secretion and defensive gastric mucosal integrity factors1, 2. Central ghrelin 44,000 ngrat dosedependently reduced ethanolinduced gastric ulcers by 3977%. The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats.
The ulcer index, lipid peroxidation and antioxidant enzyme activity gpx, catalase, sod were determined. Central ghrelin 44,000 ngrat dosedependently reduced ethanol induced gastric ulcers by 3977%. Perhaps at the highest dose consumed in this study 4. The first experiment established an additional effect of no, that gtn can help prevent emotionally induced. Gastroprotective effect of zingerone on ethanolinduced gastric. Rats of female sex weighing between 150 g 200 g were used. Tongue ulcer in a female f344n rat from a chronic study higher magnification of figure 1. Research has indicated that rats become more vulnerable to. Evaluation of antiulcer activity of hydro alcoholic extract.
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